General Information

  • ID:  hor005058
  • Uniprot ID:  B3EWJ5
  • Protein name:  Allatostatin-C1
  • Gene name:  NA
  • Organism:  Delia radicum (Cabbage root fly) (Anthomyia brassicae)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  Detected in larvae. |Expressed in the CNS and midgut but not in the ring gland, thoracic perisymapthetic organs (tPSO) or abdominal perisymapthetic organs (aPSO) (at protein level).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Delia (genus), Anthomyiinae (subfamily), Anthomyiidae (family), Muscoidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QVRYRQCYFNPISCF
  • Length:  15(1-15)
  • Propeptide:  QVRYRQCYFNPISCF
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It strongly inhibits juvenile hormone biosynthesis and may act as a neurotransmitter or neuromodulator.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45852
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005058_AF2.pdbhor005058_ESM.pdb

Physical Information

Mass: 217411 Formula: C87H126N24O22S2
Absent amino acids: ADEGHKLMTW Common amino acids: CFQRY
pI: 8.78 Basic residues: 2
Polar residues: 6 Hydrophobic residues: 4
Hydrophobicity: -34.67 Boman Index: -3376
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 45.33
Instability Index: 1563.33 Extinction Coefficient cystines: 3105
Absorbance 280nm: 221.79

Literature

  • PubMed ID:  22848525
  • Title:  Peptidomics of the agriculturally damaging larval stage of the cabbage root fly Delia radicum (Diptera: Anthomyiidae).